Thyroid hormone replacement: applying the Goldilocks principle

Excessive thyroid hormone replacement therapy.

BACKGROUND Excessive thyroid hormone replacement carries the potential for serious long-term metabolic complications (e.g., accelerated osteoporosis). The increased bioavailability of commercially available products, along with improved laboratory assays for measuring thyrotropin (TSH), has led to an increased chance of actual or detected iatrogenic hyperthyroxinemia. The purpose of this study ...

Thyroid hormone replacement one day before 131I therapy in patients with well-differentiated thyroid cancer

Objective: The current study aimed to determine the efficacy of radioiodine-131 (131I) ablation therapy with thyroid hormone replacement one day before 131I administration in patients with well-differentiated thyroid cancer (DTC). Methods: This retrospective study included 29 patients who underwent 131I therapies twice for DTC during 6-12 months.  Since all the patients obviously had residual l...

Oncogene-induced autophagy and the Goldilocks principle.

Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells undergo autophagic cell death as a result of Noxa-mediated displacement of Mcl-1...

Long-term thyroid hormone replacement therapy

In recent years the number of patients with hypothyroidism has significantly increased. It is the result of increased prevalence of autoimmune thyroid disease, increased frequency of total thyroid resections and also common radioiodine thyroid ablation in patients with hyperthyroidism or differentiated thyroid cancers. The treatment of hypothyroidism is considered by many physicians as effortle...

Whose thyroid hormone replacement is it anyway?